Case series: Slowing alpha rhythm in late-stage ALS patients

  title={Case series: Slowing alpha rhythm in late-stage ALS patients},
  author={M. Hohmann and T. Fomina and V. Jayaram and Theresa Emde and J. Just and M. Synofzik and B. Sch{\"o}lkopf and L. Sch{\"o}ls and M. Grosse-Wentrup},
  journal={Clinical Neurophysiology},
The alpha peak frequency (APF) of the human electroencephalogram (EEG) is a reliable neurophysiological marker for cognitive abilities. In these case series, we document a shift of the APF towards the lower end of the EEG spectrum in two completely locked-in ALS patients. In not completely locked-in ALS patients, the alpha rhythm lies within the common frequency range. We discuss potential implications of this shift for the largely unknown cognitive state of completely locked-in ALS patients. 
Electroencephalography of completely locked-in state patients with amyotrophic lateral sclerosis
This is the first study showing group-level EEG change of CLIS patients, though the reason for the observed EEG change cannot be concluded without any reliable communication methods with this population. Expand
The Elusive Goal of BCI-based Communication with CLIS-ALS Patients
  • M. Grosse-Wentrup
  • Medicine
  • 2019 7th International Winter Conference on Brain-Computer Interface (BCI)
  • 2019
It is argued that disease progression in amyotrophic lateral sclerosis is accompanied by a broad range of neurophysiological- and cognitive changes, which must be taken into account when designing brain-computer interfaces for this patient group. Expand
Neurophysiological aspects of the completely locked-in syndrome in patients with advanced amyotrophic lateral sclerosis
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EEG power spectral density in locked-in and completely locked-in state patients: a longitudinal study
The results show that the change in the EEG frequency spectrum may serve as an indicator of the communication ability of such patients as well as the evolution of their EEG spectrum over time with the disease’s progression. Expand
Sleep in the completely locked-in state (CLIS) in amyotrophic lateral sclerosis.
Polysomnographic recordings in eight patients in CLIS revealed the presence of regular episodes of deep sleep during night time in all patients, and it was also possible to distinguish an alpha- like state and a wake-like state. Expand
Intrinsic neural timescales related to sensory processing: Evidence from abnormal behavioural states
It is established that the spontaneous activity’s intrinsic neural timescale is related to specifically sensory rather than motor information processing in the healthy brain. Expand
Binary Semantic Classification Using Cortical Activation with Pavlovian-Conditioned Vestibular Responses in Healthy and Locked-In Individuals
Abstract To develop a more reliable brain–computer interface (BCI) for patients in the completely locked-in state (CLIS), here we propose a Pavlovian conditioning paradigm using galvanic vestibularExpand
Questioning the evidence for BCI-based communication in the complete locked-in state
The statistical analysis was replaced with a different analysis after the first review round of the comment, showing that there is no significant difference in the hemodynamic response between "yes" and "no" questions for any of the 4 patients. Expand
Workshops of the Seventh International Brain-Computer Interface Meeting: Not Getting Lost in Translation.
This paper summarizes each workshop at the BCI Meeting, providing an overview of the topic of discussion, references for additional information, and identifying future issues for research and development that resulted from the interactions and discussion at the workshop. Expand
Turning negative into positives! Exploiting "negative" results in Brain-Machine Interface (BMI) research
Results that do not confirm expectations are generally referred to as ‘negative’ results. While essential for scientific progress, they are too rarely reported in the literature – Brain–Machine Int...


EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
  • W. Klimesch
  • Psychology, Medicine
  • Brain Research Reviews
  • 1999
Evidence is presented that EEG oscillations in the alpha and theta band reflect cognitive and memory performance in particular. Good performance is related to two types of EEG phenomena (i) a tonicExpand
Peak individual alpha frequency qualifies as a stable neurophysiological trait marker in healthy younger and older adults.
Analysis of resting EEG from a large-scale training study in which healthy younger and older adults practiced 12 cognitive tasks for ∼100 1-h sessions shows IAF is highly stable in healthy adults up to 80 years, not easily modifiable by cognitive interventions alone, and thus qualifies as a stable neurophysiological trait marker. Expand
EEG alpha oscillations: The inhibition–timing hypothesis
The general conclusion is that alpha ERS plays an active role for the inhibitory control and timing of cortical processing whereas ERD reflects the gradual release of inhibition associated with the emergence of complex spreading activation processes. Expand
Increased EEG power and slowed dominant frequency in patients with neurogenic pain.
The excess theta EEG power in patients and its decrease after thalamic surgery suggests that both EEG and neurogenic pain are determined by tightly coupled thalamocortical loops. Expand
State-dependent alpha peak frequency shifts: Experimental evidence, potential mechanisms and functional implications
It is proposed that alpha frequency variability forms the basis of an adaptive mechanism mirroring the activation level of neural populations which has important functional implications. Expand
Absence of EEG correlates of self-referential processing depth in ALS
It is found that electroencephalography correlates of self-referential thinking are present in healthy individuals, but not in those with ALS, which supports the view of ALS as a complex multisystem disorder which, as shown here, includes dysfunctional processing of the medial prefrontal cortex. Expand
Brain–computer interfaces and communication in paralysis: Extinction of goal directed thinking in completely paralysed patients?
A strong correlation has been found between physical impairment and BCI performance, indicating that performance worsens as impairment increases, and whether locked-in patients can transfer learned brain control to the CLIS remains an open empirical question. Expand
Peak alpha frequency: an electroencephalographic measure of cognitive preparedness
Electroencephalographic peak alpha frequency was shown to detect both trait and state differences in cognitive preparedness, as well as to be affected by cognitive tasks. Expand
Neural oscillations involved in self-referential processing
The results indicate that non-phase-locked neural activity is involved in self-reflexive thinking and that low and high-frequency neural oscillations play different roles in emotional and cognitive aspects of self-reference processing. Expand
Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients.
It is shown that default network connectivity is decreased in severely brain-damaged patients, in proportion to their degree of consciousness impairment, as well as in healthy controls and locked-in syndrome patients. Expand