Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.

  title={Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.},
  author={Clement Adebamowo and Oyedele Adeyi and Robert Pyatt and Thomas W. Prior and Robert B. Chadwick and Albert de la Chapelle},
  journal={African journal of medicine and medical sciences},
  volume={29 1},
The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of… CONTINUE READING