Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.

@article{Morgan2010CaseRO,
  title={Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2.},
  author={Richard A. Morgan and James C-H Yang and Mio Kitano and Mark E. Dudley and Carolyn Laurencot and Steven A. Rosenberg},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 4},
  pages={
          843-51
        }
}
In an attempt to treat cancer patients with ERBB2 overexpressing tumors, we developed a chimeric antigen receptor (CAR) based on the widely used humanized monoclonal antibody (mAb) Trastuzumab (Herceptin). An optimized CAR vector containing CD28, 4-1BB, and CD3zeta signaling moieties was assembled in a gamma-retroviral vector and used to transduce autologous peripheral blood lymphocytes (PBLs) from a patient with colon cancer metastatic to the lungs and liver, refractory to multiple standard… Expand

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