Case report: pathologic long bone fracture in a patient with systemic mastocytosis.

@article{King2007CaseRP,
  title={Case report: pathologic long bone fracture in a patient with systemic mastocytosis.},
  author={Joseph J. King and Eileen A Crawford and O Hans Iwenofu and Edward J. Fox},
  journal={Clinical orthopaedics and related research},
  year={2007},
  volume={459},
  pages={263-9}
}
Systemic mastocytosis is characterized by clonal proliferation of mast cells, which cause disease by accumulating in various organs and releasing their chemical products into tissues. We highlight a patient with systemic mastocytosis that caused a pathologic femur fracture in a 63-year-old man with minimal trauma. The typical presentation of bone involvement is a combination of mixed sclerotic and osteolytic lesions, but this patient also had osteopenia. Although bone involvement is common in… CONTINUE READING