Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons.

@article{Khnert2004CaseRN,
  title={Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons.},
  author={Bianca K{\"u}hnert and Joerg Gromoll and Elena Kostova and Petra Tschanter and Craig Marc Luetjens and Manuela Simoni and Eberhard Nieschlag},
  journal={Human reproduction},
  year={2004},
  volume={19 4},
  pages={886-8}
}
Y-chromosomal microdeletions, associated with oligozoospermia or azoospermia, are usually de novo deletions in the affected patients. We report here the rare case of an affected father who transmitted a Y-chromosomal microdeletion to at least two of his three sons naturally and who also fathered a daughter. The extent of the deletion, which was determined with new STS-primers and covers 3.5 Mb, was identical in the father and his azoospermic sons. To determine any possibly modifying influence… CONTINUE READING