Case report: chromatid exchange and predivision of chromatids as other sources of abnormal oocytes detected by preimplantation genetic diagnosis of translocations.

@article{Munn1998CaseRC,
  title={Case report: chromatid exchange and predivision of chromatids as other sources of abnormal oocytes detected by preimplantation genetic diagnosis of translocations.},
  author={Santiago Munn{\'e} and Muhterem Bahçe and Tim Schimmel and Sasha Sadowy and Jacques Cohen},
  journal={Prenatal diagnosis},
  year={1998},
  volume={18 13},
  pages={1450-8}
}
Preimplantation genetic diagnosis of translocations can be performed on first polar bodies (PB) at metaphase stage using FISH with whole-chromosome painting DNA probes. Here we report the use of this method in a couple in which the female was a carrier of a balanced translocation 46,XX,t(11;16)(q21;q22). This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs, resulting in M-II oocytes with monovalent chromosomes having a… CONTINUE READING

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ChromatidsAnatomic structure is physical part ofChromosomes
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
This case unusual in that two polar bodies showed recombination events between the homologue chromosomes of 11 and 16 pairs , resulting in M - II oocytes with monovalent chromosomes having a normal and a derivative chromatid .
For this type of case , PGD analysis on polar bodies can not give a useful result , because , at the second meiotic division , either of these chromatids could remain in the oocyte , resulting in a normal , balanced or unbalanced embryo .
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