Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's disease.

@article{Deng2004CaseonlySO,
  title={Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's disease.},
  author={Yifu Deng and Beth Newman and Michael Patrick Dunne and P. A. Silburn and George Mellick},
  journal={Neuroscience letters},
  year={2004},
  volume={366 3},
  pages={326-31}
}
Current opinion contends that complex interactions between genetic and environmental factors play a role in the etiology of Parkinson's disease (PD). Cigarette smoking is thought to reduce risk of PD, and emerging evidence suggests that genetic factors may modulate smoking's effect. We used a case-only design, an approach not previously used to study gene-environment interactions in PD, specifically to study interactions between glutathione-S-transferase (GST) gene polymorphisms and smoking in… CONTINUE READING