Case-control study of human papillomavirus and oropharyngeal cancer.

  title={Case-control study of human papillomavirus and oropharyngeal cancer.},
  author={Gypsyamber D’Souza and Aim{\'e}e R. Kreimer and Raphael P. Viscidi and Michael Pawlita and Carole Fakhry and Wayne M Koch and William H. Westra and Maura Gillison},
  journal={The New England journal of medicine},
  volume={356 19},
BACKGROUND Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent. METHODS We performed a hospital-based, case-control study of 100 patients with newly diagnosed oropharyngeal cancer and 200 control patients without cancer to evaluate associations between HPV infection and oropharyngeal cancer. Multivariate logistic-regression models were used for case-control… 

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