Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.

@article{Chen2004CasecontrolSA,
  title={Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.},
  author={Wu-yan Chen and Yongyong Shi and Yong-Lan Zheng and Xin-zhi Zhao and Guang-ji Zhang and Sheng-Qi Chen and Pei-Di Yang and Lin He},
  journal={Human molecular genetics},
  year={2004},
  volume={13 23},
  pages={
          2991-5
        }
}
Genetic variants in the 22q11 gene ZDHHC8, which encodes a putative transmembrane palmitoyltransferase, has been associated to schizophrenia in family-based linkage disequilibrium (LD) studies. The single nucleotide polymorphism (SNP) rs175174 (A/G), which had the strongest association, has been shown recently to regulate the level of the fully functional transcript by modulating the retention of intron 4 of ZDHHC8. In this work, we genotyped three genetic variants within the ZDHHC8 locus and… CONTINUE READING

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