Case-control association testing in the presence of unknown relationships.

  title={Case-control association testing in the presence of unknown relationships.},
  author={Yoonha Choi and Ellen M. Wijsman and Bruce S. Weir},
  journal={Genetic epidemiology},
  volume={33 8},
Genome-wide association studies result in inflated false-positive results when unrecognized cryptic relatedness exists. A number of methods have been proposed for testing association between markers and disease with a correction for known pedigree-based relationships. However, in most case-control studies, relationships are generally unknown, yet the design is predicated on the assumption of at least ancestral relatedness among cases. Here, we focus on adjusting cryptic relatedness when the… CONTINUE READING

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