Case Series Investigating the Clinical Practice Experience of Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI) in the Clinical Management of Patients with Inflammatory Bowel Disease

@article{Good2015CaseSI,
  title={Case Series Investigating the Clinical Practice Experience of Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI) in the Clinical Management of Patients with Inflammatory Bowel Disease},
  author={Larry I Good and Raymond Michael Panas},
  journal={Journal of Gastrointestinal and Digestive System},
  year={2015},
  volume={2015}
}
  • L. Good, R. Panas
  • Published 27 March 2015
  • Medicine
  • Journal of Gastrointestinal and Digestive System
Background: Serum-derived bovine immunoglobulin/protein isolate (SBI), a specially formulated oral protein source of >50% IgG and ~60% total immunoglobulins, has a multifaceted mechanism of action binding microbial components, maintaining gastrointestinal immune balance, managing gut barrier function and improving nutrient utilization. IBD animal models and a human refractory case study demonstrated that SBI can attenuate both inflammatory biomarkers and histological parameters in the bowel… 
View via Publisher
doi.org
10 Citations
Highly Influential Citations
2
Background Citations
3

Figures from this paper

10 Citations

Clinical Efficacy of Serum‐Derived Bovine Immunoglobulin in Patients With Refractory Inflammatory Bowel Disease
Management of inflammatory bowel disease with oral serum-derived bovine immunoglobulin
TLDR
It is suggested that SBI improves clinical management of IBD patients who are not fully managed on traditional therapies and should be considered for the nutritional support of I BD regardless of disease activity, location, phenotype, duration, or complexity.
Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen
TLDR
A detailed case of pediatric UC is presented, including documentation of mucosal healing and decrease in pediatric UC activity index in a difficult to treat pediatric patient, after the addition of SBI to this patient’s treatment regimen.
Is There a Role for the Enteral Administration of Serum-Derived Immunoglobulins in Human Gastrointestinal Disease and Pediatric Critical Care Nutrition?
TLDR
Oral Ig may emerge as an important "add-on" therapy for a variety of gastrointestinal and nutritional problems during the next decade, by aiding in disease control without immunosuppressive side effects.
The Emerging Therapeutic Role of Medical Foods for Gastrointestinal Disorders.
TLDR
The history and development of medical foods under the FDA is discussed and specifically on medical foods used to help manage diseases of the gastrointestinal tract are focused on.
Long-term Management of Pouchitis-Associated Diarrhea with Serum-Derived Bovine Immunoglobulin/Protein Isolate
  • Raymond M. Panas
  • Medicine
    Clinical & Experimental Gastroenterology & Hepatology
  • 2019
TLDR
It was not until the addition of serum-derived bovine immunoglobulin/protein isolate (SBI) that 8 of 10 patients experienced satisfactory management of their pouchitis-associated diarrhea and these patients demonstrate beneficial effects in the long-term management of diarrhea-associated with pouchitis.
A Short Review on Gastrointestinal Disorders
ABSTRACT Knowledge about the psychosocial aspects of the gastrointestinal disorders is fundamental and critical to the understanding of the gastrointestinal disorders and their effective treatment.…
A Review on Recent Publications Using Microwaves in Synthesis of Biologically Active Molecules
TLDR
Applications of all microwaves in the synthesis of chemical moieties which are biologically active have been discussed with a short briefing of advantages of these techniques over the conventional approaches.
Case Series Investigating the Clinical Practice Experience of Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI) in the Clinical Management of Patients with Inflammatory Bowel Disease
TLDR
Serum-derived bovine immunoglobulin/protein isolate, a specially formulated oral protein source, has a multifaceted mechanism of action binding microbial components, maintaining gastrointestinal immune balance, managing gut barrier function and improving nutrient utilization.
Pilot Pharmacoeconomic Analysis of Serum-derived Bovine Immunoglobulin Use in IBD

References

SHOWING 1-10 OF 21 REFERENCES
A Case of Short Bowel Syndrome Managed With a Prescription Medical Food Product, Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI): 1521
TLDR
A medical food consisting of serum-derived bovine immunoglobulin/protein isolate (SBI) was utilized in a 37-year-old Caucasian female to manage SBS and may help improve nutritional status in SBS as well as manage chronic diarrhea and global symptoms of abdominal pain, bloating, and distention.
Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy
TLDR
Preliminary evidence is provided that a serum-derived bovine immunoglobulin/protein isolate is safe and improves symptoms, nutritional status, and various biomarkers associated with enteropathy in patients with HIV infection or diarrhea-predominant irritable bowel syndrome.
Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome
TLDR
This pilot study showed that nutritional therapy with either 10 g/day or 5 g/ day of SBI in 30 patients was well tolerated and resulted in statistically significant within group improvements in both symptom days and in daily symptom scores in subjects with IBS-D.
Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy
TLDR
SBI significantly increases intestinal mucosal CD4+ lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in the setting of HIV enteropathy.
New pathophysiological insights and modern treatment of IBD
TLDR
This review summarizes current epidemiology, pathogenesis and diagnostic strategies in IBD, provides insight in today’s differentiated clinical therapy and describes mechanisms of promising future medicinal approaches.
Converging goals of treatment of inflammatory bowel disease from clinical trials and practice.
TLDR
A combination of end points, comprising patient-reported outcomes and objective evaluation of inflammation by endoscopy, offers a clinically meaningful and scientifically valid alternative to existing composite indices.
Management of Loose, Frequent Stools and Fecal Incontinence in a Chronic Mesenteric Ischemia Patient with Oral Serum-derived Bovine Immunoglobulin
TLDR
This case underscores how a safe, nutritional therapy may offer a new modality for physicians to address chronic loose, frequent stools with FI in patients with CMI in this difficult to manage gastrointestinal population.
Mo1708 Serum-Derived Bovine Immunoglobulin/Protein Isolate Attenuated DSSInduced Colitis in a Defined Floral Model
Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.
TLDR
The transcriptional profile of the mucosa appears to interact with the colonic microbiota; this interaction appears to be lost in colon of patients with UC, which has different gene expression profiles and lower levels of biodiversity than their healthy twins.
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
TLDR
Upregulation of pore-forming claudin 2 and downregulation and redistribution of sealing claudins 5 and 8 lead to altered tight junction structure and pronounced barrier dysfunction already in mild to moderately active Crohn’s disease.
...
...