Case Reports of Severe Congenital Neutropenia Treated With Unrelated Cord Blood Transplantation With Reduced-intensity Conditioning.

@article{Osone2016CaseRO,
  title={Case Reports of Severe Congenital Neutropenia Treated With Unrelated Cord Blood Transplantation With Reduced-intensity Conditioning.},
  author={Shinya Osone and Toshihiko Imamura and Yoko Fukushima-Nakase and Ayaka Kitamura-Masaki and Sotaro Kanai and Tomohiko Imai and Shinsaku Imashuku and Hiroshi Kuroda},
  journal={Journal of pediatric hematology/oncology},
  year={2016},
  volume={38 1},
  pages={49-52}
}
Allogeneic stem cell transplantation is a curative treatment for severe congenital neutropenia (SCN). However, a standard conditioning regimen and donor source have not been established. We report 3 consecutive cases of SCN who were successfully treated by cord blood transplantation (CBT) with reduced-intensity conditioning consisting of fludarabine, melphalan, and low-dose total body irradiation. All cases achieved complete donor chimerism without severe infectious complications and have… CONTINUE READING
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