Case Report of Clinical Vignette: Osteopetrosis.

  title={Case Report of Clinical Vignette: Osteopetrosis.},
  author={John B. Moore and Thanh D Hoang and Alfred F Shwayhat},
  journal={Military medicine},
  volume={182 3},
INTRODUCTION Osteopetrosis is a connective tissue disorder resulting from abnormally dense bone predisposing patients to fracture. The clinical pattern of fractures across time and space as well as suggestive radiographic findings usually raises diagnostic suspicion. Multiple genetic mutations resulting in dysfunctional osteoclasts have been implicated in the pathogenesis of osteopetrosis with variable inheritance patterns. In severe cases, usually inherited in an autosomal recessive pattern… CONTINUE READING