Case Report: Fertility in a Case of Progeria

@article{Corcoy1989CaseRF,
  title={Case Report: Fertility in a Case of Progeria},
  author={Rosa Corcoy and Arifal Aris and Alberto de Leiva},
  journal={The American Journal of the Medical Sciences},
  year={1989},
  volume={297},
  pages={383–384}
}
A 32-year-old woman with Hutchinson-Gilford disease (progeria) is described. The absence of complete sexual maturation has been considered characteristic of the syndrome, but this woman delivered a normal child at the age of 23. 

Progressive Early Dermatologic Changes in Hutchinson‐Gilford Progeria Syndrome

At 18 months of age, irregular pigmentary changes of the abdomen, early occipital aiopecia, superficial scalp veins, glyphic nasal tip, absent ear lobules, coarse hair that stands on end, crowded dentition with delayed tooth development, and dystrophic nails permitted the diagnosis of progeria.

Case Report of an Iraqi Patient with Progeria and Pulmonary Fibrosis

A provisional diagnosis of progeria was made on a 16-year-old Iraqi girl with Hutchinson-Gilford progeria syndrome and pulmonary Fibrosis, which is a rare genetic disorder reported in literature as one case in eight million.

Hutchinson–Gilford progeria syndrome: Review of the phenotype

  • R. Hennekam
  • Medicine
    American journal of medical genetics. Part A
  • 2006
Patients can be subdivided in patients with classical HGPS, which follows an autosomal dominant pattern of inheritance, all cases representing spontaneous mutations, and in non‐classical progeria, in whom growth can be less retarded, scalp hair remains present for a longer time, lipodystrophy is more slowly progressive, osteolysis is more expressed except in the face, and survival well into adulthood.

Progeria: medical aspects, psychosocial perspectives, and intervention guidelines.

This article discusses progeria, a rare genetic childhood disorder that invariably results in the individual's death during early adolescence, and the psychosocial implications of the disorder with particular emphasis upon grief-triggered reactions.

Hutchinson–Gilford Progeria Syndrome: A Premature Aging Disease

A lot of research is needed to solve this mystery; hopefully, future research on HGPS would provide important clues for progeria and other fatal age-related disorders.

Review The Progerias

References

SHOWING 1-10 OF 10 REFERENCES

A Case of Progeronanism (Progeria of Gilford)

Progeronanism should be regarded as a particular form of pituitary dwarfism combined with inadequate development of tissue derived from the mesenchyme.

Progeria: a cell culture study on aging.

  • B. Danes
  • Medicine, Biology
    The Journal of clinical investigation
  • 1971
The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture.

Progeria (Hutchinson-Gilford Syndrome)

There has been no typical case of progeria reported in British literature since the original two cases, although Parsons (1949) and IsIIt IC 4 LLc 4JJ ACJ (YI ) l& Usc a typical progerian skull.

Metabolic studies in two boys with classical progeria.

The data support the concept that progeria represents a form of mesenchymal dysplasia in which connective tissue cells are unresponsive to growth influences and it is hypothesized that this failure to grow may account for the "older" collagen which may in turn produce structural abnormalities in vessel walls predisposing to atherosclerosis.

Report of a patient with typical progeria, including data from urinary hormone studies.

The necropsy findings reported by Gilford (2), Orrico and Strada (5) and Talbot et al. (6) give supportive evidence to the clinical impression of premature aging.

[On a familial nucleus of progeria].