Case-Control Analysis of SNPs in GLUT4, RBP4 and STRA6: Association of SNPs in STRA6 with Type 2 Diabetes in a South Indian Population

@inproceedings{Nair2010CaseControlAO,
  title={Case-Control Analysis of SNPs in GLUT4, RBP4 and STRA6: Association of SNPs in STRA6 with Type 2 Diabetes in a South Indian Population},
  author={Anup Kumar Nair and Divya Sugunan and H M Shashi Kumar and Gopalakrishnapillai Anilkumar},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The inverse relationship between GLUT4 and RBP4 expression is known to play a role in the pathogenesis of type 2 diabetes. Elevated levels of RBP4 were shown to cause insulin resistance in muscles and liver. Identification of STRA6 as a cell surface receptor for RBP4 provides further link in this axis and hence we analyzed SNPs in these three genes for association with type 2 diabetes in a South Indian population. METHODOLOGY/PRINCIPAL FINDINGS Selected SNPs in the three genes were… CONTINUE READING

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