Case–control matching: effects, misconceptions, and recommendations

  title={Case–control matching: effects, misconceptions, and recommendations},
  author={Mohammad Ali Mansournia and Nicholas Patrick Jewell and Sander Greenland},
  journal={European Journal of Epidemiology},
Misconceptions about the impact of case–control matching remain common. We discuss several subtle problems associated with matched case–control studies that do not arise or are minor in matched cohort studies: (1) matching, even for non-confounders, can create selection bias; (2) matching distorts dose–response relations between matching variables and the outcome; (3) unbiased estimation requires accounting for the actual matching protocol as well as for any residual confounding effects; (4… CONTINUE READING
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