Case–control association mapping by proxy using family history of disease

@article{Liu2017CasecontrolAM,
  title={Case–control association mapping by proxy using family history of disease},
  author={Jimmy Z Liu and Yaniv Erlich and Joseph K. Pickrell},
  journal={Nature Genetics},
  year={2017},
  volume={49},
  pages={325-331}
}
Collecting cases for case–control genetic association studies can be time-consuming and expensive. In some situations (such as studies of late-onset or rapidly lethal diseases), it may be more practical to identify family members of cases. In randomly ascertained cohorts, replacing cases with their first-degree relatives enables studies of diseases that are absent (or nearly absent) in the cohort. We refer to this approach as genome-wide association study by proxy (GWAX) and apply it to 12… 

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