Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate

  title={Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate},
  author={Sawako Muroi and Yoshinori Naoe and Chizuko Miyamoto and Kaori Akiyama and Tomokatsu Ikawa and Kyoko Masuda and Hiroshi Kawamoto and Ichiro Taniuchi},
  journal={Nature Immunology},
CD4 and the transcription factor ThPOK are essential for the differentiation of major histocompatibility complex class II–restricted thymocytes into the helper T cell lineage; their genes (Cd4 and Zbtb7b (called 'ThPOK' here)) are repressed by transcriptional silencer elements in cytotoxic T cells. The molecular mechanisms regulating expression of these genes during helper T cell lineage differentiation remain unknown. Here we showed that inefficient upregulation of ThPOK, induced by removal of… CONTINUE READING
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