Cascading network failure across the Alzheimer’s disease spectrum

@inproceedings{Jones2016CascadingNF,
  title={Cascading network failure across the Alzheimer’s disease spectrum},
  author={David T. Jones and David S. Knopman and Jeffrey L. Gunter and Jonathan Graff‐Radford and Prashanthi Vemuri and Bradley F. Boeve and Ronald C. Petersen and Michael W Weiner and Clifford R. Jack},
  booktitle={Brain : a journal of neurology},
  year={2016}
}
Complex biological systems are organized across various spatiotemporal scales with particular scientific disciplines dedicated to the study of each scale (e.g. genetics, molecular biology and cognitive neuroscience). When considering disease pathophysiology, one must contemplate the scale at which the disease process is being observed and how these processes impact other levels of organization. Historically Alzheimer's disease has been viewed as a disease of abnormally aggregated proteins by… CONTINUE READING

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