Cascades of sigma factors revisited.

  title={Cascades of sigma factors revisited.},
  author={P. Stragier and Richard Losick},
  journal={Molecular microbiology},
  volume={4 11},
Programmed gene expression during the process of endospore formation in Bacillus subtilis is governed by the successive appearance of five developmental sigma factors. These sigma factors are encoded by genes in which mutations arrest sporulation at a defined stage. These genes are turned on sequentially and depend for their own transcription on the activity of a previously synthesized sigma factor. Superimposed on the regulation of synthesis of the sigma factors are post-transcriptional… CONTINUE READING


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