Cascade of levodopa dose and weight-related dyskinesia in Parkinson's disease (LD-WD-PD cascade).

@article{Sharma2006CascadeOL,
  title={Cascade of levodopa dose and weight-related dyskinesia in Parkinson's disease (LD-WD-PD cascade).},
  author={Jagdish Chandra Sharma and Lorna Macnamara and Mohammad Hasoon and Michael Vassallo and Ian E Ross},
  journal={Parkinsonism & related disorders},
  year={2006},
  volume={12 8},
  pages={499-505}
}
We have studied a cohort of 220 Parkinson's disease (PD) patients for risk factors of developing new dyskinesia. Twenty-nine patients were noticed to have developed new dyskinesia at the second assessment. The dyskinetic patients received significantly higher maximum level daily dose of levodopa. These patients had lost weight during the course of the disease from 72+/-15 to 66+/-17kg, p=0.002. The dyskinetic patients received significantly higher daily dose of levodopa per kilogram body weight… CONTINUE READING

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