Cascade of gene expression induced by Ca2+ signals in neurons.

  title={Cascade of gene expression induced by Ca2+ signals in neurons.},
  author={Masashi Tsuda},
  journal={Neurochemistry international},
  volume={29 5},
To understand the cellular processes involved in learning and memory, the cellular responses of neurons to calcium (Ca2+) signals, which can be evoked via synaptic activity, should be examined. A series of investigations in primary cultures of neurons revealed that the regulation of brain-derived neurotrophic factor (BDNF) mRNA expression is mediated by almost the same Ca2+ signaling pathways as that of c-fos mRNA expression. Such early co-activation of both genes in response to Ca2+ signals… CONTINUE READING