Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination.

@article{Nguyen2013CascadeFO,
  title={Cascade fluorofunctionalisation of 2,3-unsubstituted indoles by means of electrophilic fluorination.},
  author={Tuan Minh Nguyen and Hung A Duong and J F Richard and Charles William Johannes and Fu Pincheng and Danson Kwong Jia Ye and Eileen Lau Shuying},
  journal={Chemical communications},
  year={2013},
  volume={49 90},
  pages={10602-4}
}
Cascade fluorofunctionalisation of 2,3-unsubstituted indoles featuring the formation of C-C, C-F and C-O bonds via electrophilic fluorination using N-fluorobenzenesulfonimide is described. The use of an O-nucleophile tethered to the nitrogen of indoles enables the synthesis of polycyclic fluorinated indoline derivatives from simple precursors in 40-63% yields. 

1 Figure or Table

Topics