CasFinder : Flexible algorithm for identifying specific Cas 9 targets in genomes

@inproceedings{Aach2014CasFinderF,
  title={CasFinder : Flexible algorithm for identifying specific Cas 9 targets in genomes},
  author={John Aach and Prashant Mali and George M Church},
  year={2014}
}
CRISPR/Cas9 systems enable many molecular activities to be efficiently directed in vivo to userspecifiable DNA sequences of interest, including generation of dsDNA cuts and nicks, transcriptional activation and repression, and fluorescence. CRISPR targeting relies on base pairing of short RNA transcripts with their target DNA sequences that must also be adjacent to fixed DNA motifs. However, rules for Cas9 targeting specificity are incompletely known. With increasing numbers of Cas9 systems… CONTINUE READING

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