Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells.

@article{Kamiguchi1999CasLIR,
  title={Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells.},
  author={Kenjirou Kamiguchi and Kouichi Tachibana and Satoshi Iwata and Yoshiyuki Ohashi and Chikao Morimoto},
  journal={Journal of immunology},
  year={1999},
  volume={163 2},
  pages={563-8}
}
Beta 1 integrins provide a costimulus for TCR/CD3-driven T cell activation and IL-2 production in human peripheral T cells. However, this beta 1 integrin-mediated costimulation is impaired in a human T lymphoblastic line, Jurkat. We studied the molecular basis of this impaired costimulation and found that Cas-L, a 105-kDa docking protein, is marginally… CONTINUE READING