Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.

@article{Staudacher2011CarvedilolTH,
  title={Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.},
  author={Kathrin Staudacher and Ingo Staudacher and Eckhard K. Ficker and Claudia Seyler and Jakob Gierten and Jana Kisselbach and A-K Rahm and Kathrin Trappe and Patrick Schweizer and R. Fredrick Becker and Hugo A. Katus and Dierk Thomas},
  journal={British journal of pharmacology},
  year={2011},
  volume={163 5},
  pages={
          1099-110
        }
}
BACKGROUND AND PURPOSE Human K(2P) 3.1 (TASK1) channels represent potential targets for pharmacological management of atrial fibrillation. K(2P) channels control excitability by stabilizing membrane potential and by expediting repolarization. In the heart, inhibition of K(2P) currents by class III antiarrhythmic drugs results in action potential prolongation and suppression of electrical automaticity. Carvedilol exerts antiarrhythmic activity and suppresses atrial fibrillation following cardiac… CONTINUE READING
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