Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.

@article{Koshimizu2004CarvedilolSI,
  title={Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.},
  author={Taka-Aki Koshimizu and Gozoh Tsujimoto and Akira Hirasawa and Yoko Kitagawa and Akito Tanoue},
  journal={Cardiovascular research},
  year={2004},
  volume={63 4},
  pages={662-72}
}
BACKGROUND Increasing evidence from clinical trials indicates that carvedilol, an antagonist of alpha1- and beta-adrenergic receptors (ARs), provides an effective treatment for chronic heart failure, whereas nonselective alpha1-AR blockade has an adverse outcome in this disease. It is, however, not clear whether carvedilol exhibits a subtype-dependent impact on three distinct alpha1-adrenergic receptors (alpha1-ARs). METHODS AND RESULTS We determined binding properties of human ARs for… CONTINUE READING

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