Carvedilol as a potential novel agent for the treatment of Alzheimer's disease

  title={Carvedilol as a potential novel agent for the treatment of Alzheimer's disease},
  author={Jun Wang and Kenjiro Ono and Dara L. Dickstein and Isabel Arrieta-Cruz and Wei Zhao and Xianjuan Qian and Ashley Lamparello and Rakesh Subnani and Mario Ferruzzi and Constantine Pavlides and Lap Ho and Patrick R. Hof and David B Teplow and Giulio Maria Pasinetti},
  journal={Neurobiology of Aging},
Oligomeric β-amyloid (Aβ) has recently been linked to synaptic plasticity deficits, which play a major role in progressive cognitive decline in Alzheimer's disease (AD). Here we present evidence that chronic oral administration of carvedilol, a nonselective β-adrenergic receptor blocker, significantly attenuates brain oligomeric β-amyloid content and cognitive deterioration in 2 independent AD mouse models. We found that carvedilol treatment significantly improved neuronal transmission, and… CONTINUE READING


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