Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications

@article{Kishi2019CarvedilolAB,
  title={Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications},
  author={Takuya Kishi and Eitaro Fujii},
  journal={Hypertension Research},
  year={2019},
  volume={42},
  pages={496-503}
}
Although beta blockers have been used as initial therapy for ischemic heart diseases and heart failure, the beneficial effects of beta blockers are controversial compared with other antihypertensive agents as initial therapy for hypertension without compelling indications. Moreover, atenolol has been most commonly used with beta blockers. The objective of the present systematic review associated with the Japanese Society of Hypertension (JSH) 2019 Hypertension Guideline (Clinical Question 6… 
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References

SHOWING 1-10 OF 16 REFERENCES
First-line drugs for hypertension.
TLDR
The outcomes assessed were mortality, stroke, coronary heart disease, total cardiovascular events (CVS), decrease in systolic and diastolic blood pressure, and withdrawals due to adverse drug effects, to combine dichotomous outcomes across trials and calculate risk ratio with 95% confidence interval.
Efficacy of a Once‐Daily Formulation of Carvedilol for the Treatment of Hypertension
TLDR
Carvedilol CR has a clinically meaningful defined dose‐dependent antihypertensive effect that persists throughout a 24‐hour period, and adverse events were similar in the drug‐treated and placebo groups.
Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs
TLDR
The results support an AB/CD scheme for choosing therapy, in which the first drug is taken from one of these pairs, and uncontrolled patients switch to one of the other pair.
Bisoprolol, a once‐a‐day beta‐blocking agent for patients with mild to moderate hypertension
TLDR
Results from this trial demonstrated the antihypertensive effectiveness of once‐daily bisoprolol at doses ranging from 5‐20 mg and sustained over the 24‐h dosing interval.
Beta blockers in hypertension: a review.
  • K. Kelly
  • Medicine
    American journal of hospital pharmacy
  • 1976
TLDR
It is concluded that, with proper dosage titration, most hypertensive patients could probably be controlled on beta blockers alone or in combination with a diuretic.
Effects of Carvedilol on Blood Pressure in Patients with Mild to Moderate Hypertension
TLDR
Carvedilol was well tolerated; 2 patients experienced dizziness associated with postural hypotension after administration of the 50mg dose, and the kinetics of carvedilol did not change with repeated administration.
Bisoprolol and hypertension: effects on sexual functioning in men.
TLDR
Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension and improved sexuality in some parameters, i.e. firmness of erection during coitus, contentedness with sexual functioning and satisfaction with own sexuality.
First‐Line Therapy Option with Low‐Dose Bisoprolol Fumarate and Low‐Dose Hydrochlorothiazide in Patients with Stage I and Stage II Systemic Hypertension
TLDR
The benefits of low‐dose bisoprolol 5 mg/HCTZ 6.25 mg provide a rational basis for the use of this medication in the first‐line treatment of patients with stage I and stage II systemic hypertension.
Effect of bisoprolol on blood pressure and arterial hemodynamics in systemic hypertension.
Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension.
TLDR
Antihypertensive drugs differ in their short-term effects on augmentation of the systolic pulse wave and secretion of BNP from the heart, regarded as a sensitive measure of strain on cardiomyocytes.
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