Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications

  title={Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications},
  author={Takuya Kishi and Eitaro Fujii},
  journal={Hypertension Research},
Although beta blockers have been used as initial therapy for ischemic heart diseases and heart failure, the beneficial effects of beta blockers are controversial compared with other antihypertensive agents as initial therapy for hypertension without compelling indications. Moreover, atenolol has been most commonly used with beta blockers. The objective of the present systematic review associated with the Japanese Society of Hypertension (JSH) 2019 Hypertension Guideline (Clinical Question 6… 
Study on the application effect of bisoprolol combined with sacubitril valsartan sodium tablets in the cardiac rehabilitation of patients with acute myocardial infarction combined with left heart failure after percutaneous coronary intervention (PCI).
Bisoprolol combined with sacubitril valsartan sodium tablets has a good application effect in the cardiac rehabilitation of patients with acute myocardial infarction combined with left heart failure after PCI and can promote cardiac rehabilitation and improve cardiac function, and reduce the incidence of cardiac adverse events.
Recommended Management of Hypertensive Patients with Diabetes for Renin-Angiotensin System (RAS) Inhibitors
RAS (ACE inhibitors and ARB) would be recommended to be a first-line treatment when providing antihypertensive agents for hypertensive patients with diabetes, cardiovascular disease, and impaired renal function.
Heart rate Is the Clinical Indicator of Sympathetic Activation and Prognostic Value of Cardiovascular Risks in Patients With Hypertension.
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  • Medicine, Biology
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The results clearly indicated that patients with hypertension with HR >80 beats/minute could be characterized by a marked sympathetic overactivation, and that cardiac and peripheral sympathetic activation are involved in the increased cardiovascular risk detected in this group of patients.
Role of TLR-4/IL-6/TNF-α, COX-II and eNOS/iNOS pathways in the impact of carvedilol against hepatic ischemia reperfusion injury
CAR protects liver from I/R injury through reduction of the oxidative stress and inflammation, and modulates endothelial and inducible nitric oxide synthase expressions.
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
The story of the life and times of Toshihiko Umemura and his family in the years leading up to and including his death.


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Carvedilol CR has a clinically meaningful defined dose‐dependent antihypertensive effect that persists throughout a 24‐hour period, and adverse events were similar in the drug‐treated and placebo groups.
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The results support an AB/CD scheme for choosing therapy, in which the first drug is taken from one of these pairs, and uncontrolled patients switch to one of the other pair.
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Results from this trial demonstrated the antihypertensive effectiveness of once‐daily bisoprolol at doses ranging from 5‐20 mg and sustained over the 24‐h dosing interval.
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It is concluded that, with proper dosage titration, most hypertensive patients could probably be controlled on beta blockers alone or in combination with a diuretic.
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Carvedilol was well tolerated; 2 patients experienced dizziness associated with postural hypotension after administration of the 50mg dose, and the kinetics of carvedilol did not change with repeated administration.
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Bisoprolol is an effective antihypertensive drug with no detrimental effects on sexuality in newly diagnosed men with hypertension and improved sexuality in some parameters, i.e. firmness of erection during coitus, contentedness with sexual functioning and satisfaction with own sexuality.
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The benefits of low‐dose bisoprolol 5 mg/HCTZ 6.25 mg provide a rational basis for the use of this medication in the first‐line treatment of patients with stage I and stage II systemic hypertension.
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Antihypertensive drugs differ in their short-term effects on augmentation of the systolic pulse wave and secretion of BNP from the heart, regarded as a sensitive measure of strain on cardiomyocytes.