Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity

Abstract

The membrane voltage clock and calcium (Ca2+) clock jointly regulate sinoatrial node (SAN) automaticity. VK-II-36 is a novel carvedilol analog that suppresses sarcoplasmic reticulum (SR) Ca2+ release but does not block the β-receptor. The effect of VK-II-36 on SAN function remains unclear. The purpose of this study was to evaluate whether VK-II-36 can… (More)
DOI: 10.1007/s00380-013-0378-2

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