Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation.

@article{Eid2016CarvedilolAT,
  title={Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation.},
  author={Ahmed H. Eid and Noha F Abdelkader and Ola M Abd El-Raouf and Hala M. Fawzy and Ezz-El-Din S. El-Denshary},
  journal={Archives of pharmacal research},
  year={2016},
  volume={39 12},
  pages={1693-1702}
}
The clinical application of the anticancer drug cisplatin is limited by its deleterious side effects, including male reproductive toxicity. In this context, the potential protective effect of carvedilol on testicular and spermatological damage induced by cisplatin in male Sprague-Dawley rats was investigated. Carvedilol was orally administered at a dose of 10 mg/kg for 2 weeks, and cisplatin was given as a single intraperitoneal injection of 10 mg/kg on the 12th day to induce toxicity… CONTINUE READING