Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy

@inproceedings{Arozal2011CarvedilolAffordedPA,
  title={Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy},
  author={Wawaimuli Arozal and Flori R. Sari and Kenichi Watanabe and Somasundaram Arumugam and Punniyakoti Thanikachalam Veeraveedu and Meilei Ma and Rajarajan A Thandavarayan and Vijayakumar Sukumaran and Arun Prasath Lakshmanan and Yoshiyasu Kobayashi and Sayaka Mito and Vivian Soetikno and Kenji Suzuki},
  booktitle={ISRN pharmacology},
  year={2011}
}
Anthracyclines, most powerful anticancer agents, suffer from their cardiotoxic effects, which may be due to the induction of oxidative stress. Carvedilol, a third-generation, nonselective β-adrenoreceptor antagonist, possesses both reactive oxygen species (ROS) scavenging and ROS suppressive effects. It showed protective effects against daunorubicin- (DNR-) induced cardiac toxicity by reducing oxidative stress and apoptosis. This study therefore was designed to examine the effects of carvedilol… CONTINUE READING
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