Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

  title={Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note},
  author={Thorsteinn Loftsson and Stine Byskov Vogensen and Cyrielle Desbos and Phatsawee Jansook},
  journal={AAPS PharmSciTech},
Carvedilol (Table I) is a non-selective β-blocker indicated in the treatment of mild to moderate congestive heart failure. It also has vasodilating properties that are mainly attributed to its α1-blocking activity, as well as ability to inhibit oxidative stress in coronary smooth muscle (1). It is marketed under various trade names including Eucardic (Roche), Dilatrend (Roche), Kredex (Roche) and Coreg (GlaxoSmithKline). Carvedilol is well absorbed after oral administration, but is subject to… CONTINUE READING


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