Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice.

@article{Alvarenga2017CarvacrylAA,
  title={Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice.},
  author={Elenice M Alvarenga and Nayara Alves de Sousa and Simone de Ara{\'u}jo and Jos{\'e} Luiz Pita Junior and Alyne Rodrigues de Ara{\'u}jo and Bruno Iles and Dvison M. Pac{\'i}fico and Gerly A C Brito and Eduardo Pinheiro de Souza and Dami{\~a}o P Sousa and Jand Venes R Medeiros},
  journal={The Journal of pharmacy and pharmacology},
  year={2017},
  volume={69 12},
  pages={
          1773-1785
        }
}
OBJECTIVES We aimed to determine whether carvacryl acetate acts as a TRPA1 receptor agonist and its effects against irinotecan (CPT-11) induced intestinal mucositis in mice. METHODS TRPA1 structure was obtained from a protein databank, and the 3D structure of carvacryl acetate was determined. Appropriate binding conformations were discovered via automatic docking simulations. To determine the effect of carvacryl acetate in vivo, mice were treated with either DMSO 2%, CPT-11, carvacryl acetate… CONTINUE READING
BETA

Similar Papers

Loading similar papers…