Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

@article{Chng2020CartographyOO,
  title={Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment},
  author={Kern Rei Chng and Chenhao Li and D. Bertrand and A. Ng and Junmei Samantha Kwah and H. M. Low and C. Tong and M. Natrajan and M. H. Zhang and Licheng Xu and K. Ko and E. Ho and Tamar V Av-Shalom and J. Teo and C. Khor and B DavidDanielaEbrahimSofiaChandrimaDanielJ.KernReiDankoBezdanAfshinnekooAhsanuddinBhattacharya and D. Danko and D. Bezdan and Ebrahim Afshinnekoo and Sofia Ahsanuddin and Chandrima Bhattacharya and D. Butler and Francesca De Filippis and J. Hecht and Andr{\'e} Kahles and Mikhail Karasikov and N. Kyrpides and M. Leung and D. Meleshko and Harun Mustafa and B. Mutai and R. Neches and M. Nieto-Caballero and O. Nikolayeva and T. Nikolayeva and Eileen Png and Jorge L. Sanchez and H. Shaaban and M. Sierra and Xinzhao Tong and B. Young and Josue Alicea and M. Bhattacharyya and Ran Blekhman and E. Castro-Nallar and Ana M. Ca{\~n}as and A. Chatziefthimiou and R. Crawford and Youping Deng and C. Desnues and E. Dias-Neto and Daisy Donnellan and M. Dybwad and E. Elhaik and D. Ercolini and A. Frolova and Alexandra B. Graf and D. Green and Iman Hajirasouliha and Mark T. Hern{\'a}ndez and G. Iraola and Soojin Jang and Angela Jones and F. Kelly and Kaymisha Knights and Paweł P. Łabaj and Patrick K. H. Lee and Levy Shawn and P. Ljungdahl and Abigail Lyons and G. Mason-Buck and K. McGrath and E. Mongodin and M. Moraes and N. Nagarajan and H. Noushmehr and Manuela Oliveira and S. Ossowski and O. Osuolale and Orhan {\"O}zcan and David P{\'a}ez-Espino and N. Rascovan and H. Richard and G. R{\"a}tsch and L. Schriml and T. Semmler and O. U. Sezerman and Leming Shi and L. Song and Haruo Suzuki and D. Court and Dominique Thomas and S. Tighe and K. Udekwu and J. Ugalde and Brandon Valentine and D. Vassilev and Elena M. Vayndorf and T. Velavan and M. Zambrano and Jifeng Zhu and Sibo Zhu and C. Mason and S. Chen and O. Ng and K. Marimuthu and B. Ang},
  journal={Nature Medicine},
  year={2020},
  volume={26},
  pages={941 - 951}
}
Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes characterized… Expand
20 Citations
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