Cartilaginous Fishes Provide Insights into the Origin, Diversification, and Sexually Dimorphic Expression of Vertebrate Estrogen Receptor Genes

@article{Filowitz2018CartilaginousFP,
  title={Cartilaginous Fishes Provide Insights into the Origin, Diversification, and Sexually Dimorphic Expression of Vertebrate Estrogen Receptor Genes},
  author={Grant L Filowitz and Rajendhran Rajakumar and Katherine L O’Shaughnessy and Martin J. Cohn},
  journal={Molecular Biology and Evolution},
  year={2018},
  volume={35},
  pages={2695–2701}
}
Vertebrate estrogen receptors (ERs) perform numerous cell signaling and transcriptional regulatory functions. ERɑ (Esr1) and ERβ (Esr2) likely evolved from an ancestral receptor that duplicated and diverged at the protein and cis-regulatory levels, but the evolutionary history of ERs, including the timing of proposed duplications, remains unresolved. Here we report on identification of two distinct ERs in cartilaginous fishes and demonstrate their orthology to ERα and ERβ. Phylogenetic analyses… Expand
4 Citations
Cartilaginous fishes offer unique insights into the evolution of the nuclear receptor gene repertoire in gnathostomes.
TLDR
It is shown that cartilaginous fish retain an archetypal NR gene repertoire, similar to that of mammals and coincident with the two rounds of whole genome duplication that occurred in the gnathostome ancestor. Expand
Steroid receptors and vertebrate evolution
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  • Molecular and Cellular Endocrinology
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Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids, and sex steroids, also are young, with an estrogen receptor and a 3-ketosteroid receptor first appearing in basal chordates (cephalochordates: amphioxus). Expand
Steroid Receptors and Vertebrate Evolution
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Sex steroids as mediators of phenotypic integration, genetic correlations, and evolutionary transitions
  • R. Cox
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • 2020
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The rapidly increasing availability of genomic and transcriptomic data from non-model organisms places evolutionary endocrinologist in an excellent position to address the hormonal regulation of the key evolutionary interface between genes and phenotypes. Expand

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