Cartilage metabolism and anti-inflammatory drugs in osteoarthritis.

  title={Cartilage metabolism and anti-inflammatory drugs in osteoarthritis.},
  author={Evelyn V. Hess and Jerome H. Herman},
  journal={The American journal of medicine},
  volume={81 5B},
The issue of selecting nonsteroidal anti-inflammatory drugs (NSAIDs) for the management of osteoarthritis based upon their direct effect on normal cartilage metabolism and their ability to modulate mechanisms that disturb such metabolism is addressed. This article provides an overview of the anatomic and biochemical changes that occur in diseased synovial tissue and cartilage, and the pathophysiologic mechanisms presumed to function in the induction and perpetuation of cartilage failure… CONTINUE READING


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