Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

  title={Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.},
  author={S M Seyedin and Andrea Y. Thompson and H L Bentz and David M. Rosen and John M. McPherson and Amedeo Conti and Norbert Siegel and Gerald R. Galluppi and Karl A. Piez},
  journal={The Journal of biological chemistry},
  volume={261 13},
Comparison of the sequence of the N-terminal 30 amino acids of cartilage-inducing factor-A (CIF-A) from bovine demineralized bone with the corresponding sequence of human transforming growth factor-beta (TGF-beta) revealed 100% identity. Furthermore, CIF-A stimulated normal rat kidney fibroblasts to become anchorage-independent and form colonies in soft agar (in the presence of epidermal growth factor) in a manner similar to TGF-beta. Similarly, TGF-beta from human platelets induced rat muscle… CONTINUE READING
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