Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction.

@article{Chen2012CartilageFF,
  title={Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction.},
  author={Chia-Chun Chen and Cheng-Hao Liao and Yao-Horng Wang and Yuan-Ming Hsu and Shih-Horng Huang and Chih-Hung Chang and Hsu-Wei Fang},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2012},
  volume={30 3},
  pages={393-400}
}
Extracellular matrix (ECM) is thought to participate significantly in guiding the differentiation process of mesenchymal stem cells (MSCs). In this study, we hypothesized that cartilage fragments from osteoarthritic knee could promote chondrogenesis of MSCs. Nonworn parts of cartilage tissues were obtained during total knee arthroplasty (TKA) surgery. Cartilage fragments and MSCs were wrapped into fibrin glue; and the constructs were implanted subcutaneously into nude mice. Histological… CONTINUE READING