Cartilage dysplasia and tissue mineralization in the rat following administration of a FGF receptor tyrosine kinase inhibitor.

@article{Brown2005CartilageDA,
  title={Cartilage dysplasia and tissue mineralization in the rat following administration of a FGF receptor tyrosine kinase inhibitor.},
  author={Alan P. Brown and Cynthia L. Courtney and Lena M. King and Stephen C Groom and Michael J. Graziano},
  journal={Toxicologic pathology},
  year={2005},
  volume={33 4},
  pages={449-55}
}
PD176067 is a reversible and selective inhibitor of fibroblast growth factor receptor tyrosine kinase, and was in preclinical development as an angiogenesis inhibitor for the treatment of solid tumors. A 14-day oral toxicity study of PD176067 in young female rats (7 weeks old) was conducted at doses of 2.5, 5, and 10 mg/kg/day (15, 30, and 60 mg/m(2), respectively). Skeletal changes, and vascular and soft tissue mineralization were observed as primary drug-related toxicities. To determine if… CONTINUE READING

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Mineralization of cardiac myocytes , aorta , various arteries , renal tubules , and gastric mucosa and muscularis was seen at 10 mg / kg , and consistent with the presence of calcium - phosphorus deposition .
Mineralization of cardiac myocytes , aorta , various arteries , renal tubules , and gastric mucosa and muscularis was seen at 10 mg / kg , and consistent with the presence of calcium - phosphorus deposition .
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