Cartilage destruction is partly induced by the internal proteolytic enzymes and apoptotic phenomenon of chondrocytes in relapsing polychondritis.

@article{Ouchi2011CartilageDI,
  title={Cartilage destruction is partly induced by the internal proteolytic enzymes and apoptotic phenomenon of chondrocytes in relapsing polychondritis.},
  author={Naohisa Ouchi and Miwa Uzuki and Akihisa Kamataki and Yasuhiro Miura and Terumitsu Sawai},
  journal={The Journal of rheumatology},
  year={2011},
  volume={38 4},
  pages={
          730-7
        }
}
OBJECTIVE We analyzed 9 cases by immunohistochemical studies in order to elucidate the mechanisms of cartilage destruction in relapsing polychondritis (RP), which often involves the external auricle and respiratory tract through immunological disorder. METHODS Cartilage tissues were obtained during surgical operations. Cell species in the granulation tissues, especially near the cartilage, were identified by cell-surface markers [CD3, CD4, CD8, CD20, CD45 (LCA), and CD68]. The proteolytic… CONTINUE READING
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