Cartilage-derived morphogenetic proteins induce osteogenic gene expression in the C2C12 mesenchymal cell line.

@article{Yeh2005CartilagederivedMP,
  title={Cartilage-derived morphogenetic proteins induce osteogenic gene expression in the C2C12 mesenchymal cell line.},
  author={Lee-chuan C. Yeh and Alicia D Tsai and John C. H. Lee},
  journal={Journal of cellular biochemistry},
  year={2005},
  volume={95 1},
  pages={
          173-88
        }
}
Cartilage-derived morphogenetic protein-1, -2, and -3 (CDMP-1, -2, and -3) are members of the bone morphogenetic protein (BMP) family and have been shown to exhibit a variety of biological activities. In the present study, effects of these CDMPs on the temporal and spatial expression of genes in the pluripotent mesenchymal cell line C2C12 were examined. Cells cultured in the presence of CDMPs lost the characteristic elongated shape of myoblasts. At the molecular level, CDMP treatment did not… CONTINUE READING
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