Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis.

@article{Bobacz2002CartilagederivedMP,
  title={Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis.},
  author={Klaus Bobacz and Rudolf Gruber and Afschin Soleiman and Winfried B. Graninger and Frank P. Luyten and Ludwig Erlacher},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 5},
  pages={394-401}
}
OBJECTIVE We investigated whether chondrocytes derived from osteoarthritic cartilage may lose their responsiveness to cartilage-derived morphogenetic protein-1, -2 (CDMP-1, -2) and osteogenic protein-1 (OP-1) compared with healthy cells, thus leading to an impaired maintenance of matrix integrity. DESIGN Chondrocytes were isolated from articular cartilage from patients with and without osteoarthritic lesions. Cells were grown as monolayer cultures for 7 days in a chemically defined serum-free… CONTINUE READING

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