Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.

  title={Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.},
  author={Yasufumi Sato and Masumi Iketani and Yuji Kurihara and Megumi Yamaguchi and Naoya Yamashita and Fumio Nakamura and Yuko Arie and Takahiko Kawasaki and Tatsumi Hirata and Takaya Abe and Hiroshi Kiyonari and Stephen M Strittmatter and Yoshio Goshima and Kohtaro Takei},
  volume={333 6043},
Neural circuitry formation depends on the molecular control of axonal projection during development. By screening with fluorophore-assisted light inactivation in the developing mouse brain, we identified cartilage acidic protein-1B as a key molecule for lateral olfactory tract (LOT) formation and named it LOT usher substance (LOTUS). We further identified Nogo receptor-1 (NgR1) as a LOTUS-binding protein. NgR1 is a receptor of myelin-derived axon growth inhibitors, such as Nogo, which prevent… CONTINUE READING

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