Cartilage Regeneration of Adipose-Derived Stem Cells in the TGF-β1-Immobilized PLGA-Gelatin Scaffold

@article{Yin2014CartilageRO,
  title={Cartilage Regeneration of Adipose-Derived Stem Cells in the TGF-β1-Immobilized PLGA-Gelatin Scaffold},
  author={Feng Yin and Junfeng Cai and Wen Bin Zen and Yanhui Wei and Wei Zhou and Fu-yu Yuan and Shree Ram Singh and Yiyong Wei},
  journal={Stem Cell Reviews and Reports},
  year={2014},
  volume={11},
  pages={453-459}
}
Articular cartilage has restricted self-regenerative capacity; therefore, treatment of cartilage lesions is a great challenge in the field of orthopedics. In the present study, we evaluate the enhancing effect of a transforming growth factor-beta 1 (TGF-β1)-immobilized scaffold, fabricated by incorporating TGF-β1-loaded gelatin microspheres into PLGA framework, on the differentiation of adipose-derived stem cells (ASCs) into chondrocytes. Significant increase in cell proliferation was observed… CONTINUE READING
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