Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.

  title={Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.},
  author={Malcolm W. B. McCulloch and Tim S Bugni and Gisela P. Concepcion and Gary S. Coombs and Mary Kay Harper and Simran Kaur and Gina C. Mangalindan and Misha M. Mutizwa and Charles A. Veltri and David M Virshup and Chris M. Ireland},
  journal={Journal of natural products},
  volume={72 9},
Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were… CONTINUE READING