Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.

@article{McCulloch2009CarteriosulfonicAA,
  title={Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.},
  author={Malcolm W. B. McCulloch and Tim S. Bugni and Gisela P. Concepcion and Gary S. Coombs and Mary Kay Harper and Simran Kaur and Gina C. Mangalindan and Misha M. Mutizwa and Charles A. Veltri and David M. Virshup and Chris M. Ireland},
  journal={Journal of natural products},
  year={2009},
  volume={72 9},
  pages={
          1651-6
        }
}
Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were… 

Figures from this paper

α‐Pyrones and Pyranes from the Plant Pathogenic Fungus Pestalotiopsis scirpina

Three new α-pyrones, scirpyrones A–C (1–3), and four new pyranes, scirpyranes A–D (4–7), were isolated from solid cultures of the plant pathogen Pestalotiopsis scirpina. Their structures were

Kinase Inhibitors from Marine Sponges

TLDR
Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases, which belong to diverse structural classes and are ordered based upon the kinase that they inhibit.

Cytotoxic Glycosylated Fatty Acid Amides from a Stelletta sp. Marine Sponge.

TLDR
New glycosylated fatty acid amides, stellettosides, from a Stelletta sp.

Cytotoxic diterpenoid pseudodimers from the Korean sponge Phorbas gukhulensis.

TLDR
Four new cytotoxic diterpenoid pseudodimers (2-5) were isolated from the marine sponge Phorbas gukhulensis collected off the coast of Gagu-do, Korea, and exhibited significant cytotoxicity against the K562 and A549 cell lines.

Melonoside B and Melonosins A and B, Lipids Containing Multifunctionalized ω-Hydroxy Fatty Acid Amides from the Far Eastern Marine Sponge Melonanchora kobjakovae.

TLDR
Melonosins 2 and 3 inhibit AP-1- and NF-kB-dependent transcriptional activities in JB6 Cl41 cells at noncytotoxic concentrations, demonstrating potential cancer preventive activity.

Anticancer compounds from Philippine marine organisms act on major pathways in cancer

TLDR
To address the challenges associated with developing marine natural products for the pharmaceutical drug pipeline, future directions will focus on optimizing the culture of marine organisms and symbionts, utilizing biosynthetic genes in microbial hosts, and developing the concept of treating cancer with combinatorial therapy.

Tetrahydroanthraquinone and xanthone derivatives from the marine-derived fungus Trichoderma aureoviride PSU-F95

TLDR
Known coniothranthraquinone 1 and emodin displayed strong antibacterial activity against methicillin-resistant Staphylococcus aureus with the MIC values of 8 and 4 μg/mL, respectively.

Chemical and biological diversity of new natural products from marine sponges: a review (2009–2018)

TLDR
Alkaloids, terpenoids, and steroids were the major contributors to antibacterial, antifungal, and antioxidant activities while steroids were primarily responsible for pest resistance activity.

Targeting the wingless signaling pathway with natural compounds as chemopreventive or chemotherapeutic agents.

TLDR
Findings underline the fact that Wnt signaling could be considered as a promising target for innovative strategies for cancer treatment and prevention.

References

SHOWING 1-5 OF 5 REFERENCES

Tables of spectral data for structure determination of organic compounds

"This book contains tables and charts of spectrum-structure correlations for all major spectroscopic techniques (C13-NMR, 1H-NMR, IR, MS, UV/VIS). It has been designed for those who are routinely

References and Notes

our experimentation could eventually be used to discredit our findings, should they happen not to agree with the original observations. It seems important that all experiments in the rapidly

2H, m, H-20), 1.62 (2H, m, H-3), 1.51-1.41 (2H, m, H-14), 1.29-1.25 (broad overlapped methylene peak), 0.87 (3H, m, H-22); 13 C NMR (CDCl 3 , 125 MHz) δ 174.6 (C-1

  • MPA-ester carbonyl), 136.7 (aromatic), 135.2 (olefinic), 134.8 (olefinic), 130.2 (olefinic), 128.8 (aromatic), 128.5 (aromatic)

Tetrahedron: Asymmetry 2001;12:2915–2925

  • 2001

Molecules 2008;13:1372–1383

  • McCulloch et al. Page 7 J Nat Prod. Author manuscript; available in PMC 2010 September 1. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript
  • 2010