Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.

  title={Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.},
  author={Malcolm W. B. McCulloch and Tim S. Bugni and Gisela P. Concepcion and Gary S. Coombs and Mary Kay Harper and Simran Kaur and Gina C. Mangalindan and Misha M. Mutizwa and Charles A. Veltri and David M. Virshup and Chris M. Ireland},
  journal={Journal of natural products},
  volume={72 9},
Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were… 

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Tables of spectral data for structure determination of organic compounds

"This book contains tables and charts of spectrum-structure correlations for all major spectroscopic techniques (C13-NMR, 1H-NMR, IR, MS, UV/VIS). It has been designed for those who are routinely

References and Notes

our experimentation could eventually be used to discredit our findings, should they happen not to agree with the original observations. It seems important that all experiments in the rapidly

2H, m, H-20), 1.62 (2H, m, H-3), 1.51-1.41 (2H, m, H-14), 1.29-1.25 (broad overlapped methylene peak), 0.87 (3H, m, H-22); 13 C NMR (CDCl 3 , 125 MHz) δ 174.6 (C-1

  • MPA-ester carbonyl), 136.7 (aromatic), 135.2 (olefinic), 134.8 (olefinic), 130.2 (olefinic), 128.8 (aromatic), 128.5 (aromatic)

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