Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.

@article{Lai2006CarrierPS,
  title={Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.},
  author={Jonathan R Lai and Alexander Koglin and Christopher T Walsh},
  journal={Biochemistry},
  year={2006},
  volume={45 50},
  pages={
          14869-79
        }
}
Carrier proteins, 80-100 residues in length, serve as information-rich platforms to present growing acyl and peptidyl chains as covalently tethered phosphopantetheinyl-thioester intermediates during the biosynthesis of fatty acid, polyketide, and nonribosomal natural products. Carrier proteins are recognized both in cis and in trans by partner catalytic domains that effect chain-elongating condensations, redox adjustments, other tailoring steps, and finally kinetically controlled disconnection… CONTINUE READING

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