Carrier-mediated uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small-molecule survivin suppressant, into human solid tumor and lymphoma cells.

@article{Minematsu2009CarriermediatedUO,
  title={Carrier-mediated uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small-molecule survivin suppressant, into human solid tumor and lymphoma cells.},
  author={Tsuyoshi Minematsu and Megumi Iwai and Kenji Sugimoto and Nobuaki Shirai and Takahito Nakahara and Takashi Usui and Hidetaka Kamimura},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 3},
  pages={619-28}
}
1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide) is a novel small-molecule survivin suppressant that induces the down-regulation of survivin and exhibits potent antitumor activity in nude mice bearing the human hormone refractory prostate carcinoma cell line PC-3. In this study, radioluminographic determination of the in vivo distribution of radioactivity after administration of [(14)C]YM155 to PC-3-xenografted… CONTINUE READING

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Therefore , the uptake of [ ( 14)C]YM155 was further characterized in vitro using PC-3 , lung cancer ( Calu-6 and NCI - H358 ) , malignant melanoma ( A375 and SK - MEL-5 ) , and non - Hodgkin 's lymphoma ( RL and Ramos ) cell lines .
Therefore , the uptake of [ ( 14)C]YM155 was further characterized in vitro using PC-3 , lung cancer ( Calu-6 and NCI - H358 ) , malignant melanoma ( A375 and SK - MEL-5 ) , and non - Hodgkin 's lymphoma ( RL and Ramos ) cell lines .
To summarize , YM155 was taken up into cancer cells in a carrier - mediated manner and with a similar affinity among all the cancer cell lines tested .
To summarize , YM155 was taken up into cancer cells in a carrier - mediated manner and with a similar affinity among all the cancer cell lines tested .
To summarize , YM155 was taken up into cancer cells in a carrier - mediated manner and with a similar affinity among all the cancer cell lines tested .
To summarize , YM155 was taken up into cancer cells in a carrier - mediated manner and with a similar affinity among all the cancer cell lines tested .
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