Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.

@article{Goldman1968CarriermediatedTO,
  title={Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.},
  author={I. Goldman and N. Lichtenstein and V. Oliverio},
  journal={The Journal of biological chemistry},
  year={1968},
  volume={243 19},
  pages={
          5007-17
        }
}
  • I. Goldman, N. Lichtenstein, V. Oliverio
  • Published 1968
  • Medicine, Chemistry
  • The Journal of biological chemistry
  • Abstract Transport of methotrexate (4-amino-10-methylpteroyl-glutamic acid), a structural analogue of folic acid, was studied in L1210 mouse leukemia cells grown in tissue culture. Intracellular methotrexate was present in two states. (a) There was an essentially nonexchangeable intracellular fraction probably bound to the enzyme dihydrofolate reductase. (b) The remaining intracellular methotrexate was rapidly exchangeable and likely present in the cell water in an osmotically active state. In… CONTINUE READING
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