Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes.

  title={Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes.},
  author={Frank Tietze and Leonard D. Kohn and Aimee D. Kohn and Isa M Bernardini and Hans Christer Andersson and Megan D Adamson and Gregory S. Harper and William A Gahl},
  journal={The Journal of biological chemistry},
  volume={264 9},
Monoiodotyrosine (MIT) crosses the lysosomal membrane of rat FRTL-5 thyroid cells by a carrier-mediated process. In egress studies, MIT lost from inside lysosomes was quantitatively recovered outside lysosomes as MIT, indicating that the compound was transported intact across the lysosomal membrane. In uptake studies, [125I]MIT entry required intact… CONTINUE READING